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Treatment of erectile dysfunction: from pills to modern interventions

Treatment of erectile dysfunction: from pills to modern interventions
Useful information
April 13, 2026Valentin Iordache

Introduction

Erectile dysfunction is a common problem that affects millions of men globally, including a significant percentage of patients with diabetes mellitus. Although it can have a major impact on quality of life, it is important to know that erectile dysfunction can be treated effectively in most cases.

Currently, there is a wide range of therapeutic options — from simple oral treatments to modern procedures and surgical interventions.

The choice of treatment depends on the cause, severity, and individual characteristics of each patient.

What should be evaluated before treatment?

Before initiating therapy, it is essential to identify the cause of erectile dysfunction:

  • vascular cause
  • neurological cause
  • hormonal cause
  • psychological cause
  • mixed forms (very common, especially in diabetes)

Evaluation may include:

  • diabetology and urology consultation
  • blood tests (glucose, HbA1c, testosterone)
  • penile Doppler ultrasound
  • cardiovascular evaluation

Correct treatment always begins with correct diagnosis.

1. First-line treatment: oral medication (PDE5 inhibitors)

What are PDE5 inhibitors?

They are the most commonly used medications in the treatment of erectile dysfunction:

  • sildenafil (Viagra)
  • tadalafil
  • vardenafil

How do they work?

These medications:

  • increase the effect of nitric oxide
  • relax blood vessels
  • increase blood flow to the penis

Result: firmer and easier to achieve erection

Advantages

  • easy to administer
  • effective in many cases
  • rapid action

Limitations

  • require sexual stimulation
  • not effective in all cases (e.g., severe neuropathy)
  • may have contraindications (e.g., treatment with nitrates)

Efficacy

- approximately 60–70% of patients respond to treatment
- efficacy is reduced in patients with advanced diabetes

2. Shockwave therapy

What is it?

A modern, non-invasive method that uses low-intensity shockwaves to stimulate vascular regeneration.

How does it work?

  • stimulates formation of new blood vessels
  • improves endothelial function
  • increases penile blood flow

For whom is it recommended?

  • erectile dysfunction from vascular cause
  • patients who do not respond optimally to oral medication

Advantages

  • non-invasive
  • painless
  • no significant adverse effects
  • can improve the cause, not just the symptom

Limitations

  • requires multiple sessions
  • results appear progressively

3. Intracavernous injections

What do they involve?

Direct administration of medication into the penis, which produces erection.

How do they work?

  • cause rapid vasodilation
  • induce erection independent of sexual stimulus

Advantages

  • high efficacy (over 80%)
  • works even in severe cases

Disadvantages

  • requires training
  • possible discomfort
  • small risk of complications (e.g., priapism)

4. Vacuum devices (penile pumps)

How do they work?

  • create negative pressure
  • draw blood into the penis
  • maintain erection with the help of a ring

Advantages

  • non-invasive
  • no medication
  • good option for patients with contraindications

Limitations

  • less spontaneous
  • variable acceptability

5. Hormonal treatment

When is it necessary?

In patients with:

  • low testosterone levels
  • reduced libido

What does it involve?

  • testosterone replacement therapy
  • careful medical monitoring

Benefits

  • increased sexual desire
  • improved response to treatment

6. Penile prosthesis – the definitive solution

What is it?

A surgically implanted device that allows achievement of mechanical erection.

Types

  • malleable prostheses
  • inflatable prostheses

When is it indicated?

  • severe cases
  • lack of response to other treatments

Advantages

  • very high efficacy
  • high satisfaction

Disadvantages

  • surgical intervention
  • higher costs

7. The role of lifestyle

Treatment is not complete without:

  • optimal glycemic control
  • weight loss
  • physical activity
  • smoking cessation

These measures can significantly improve erectile function.

Integrated approach – the key to success

Erectile dysfunction, especially in diabetes, requires: collaboration between diabetologist and urologist

treatment of the cause + treatment of the symptom = optimal results

When should you see a doctor?

  • weak or absent erections
  • lack of response to treatment
  • uncontrolled diabetes
  • decreased libido

Conclusion

Treatment of erectile dysfunction has evolved significantly in recent years. From pills to modern therapies and surgical interventions, there are solutions for almost every patient.

The correct choice of treatment depends on diagnosis, and early intervention significantly increases the chances of success.

If you are facing erectile dysfunction, a complete evaluation (diabetological + urological) can identify the cause and offer the right solution.

Schedule a consultation for a personalized treatment plan.

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